Osteoporosis and its consequences has become a major problem threatening the health of the elderly. Investigate osteoporosis risk factors and the potential for effective interventions study, Play a part in improve the level of Pain in the elderly may prevention of falls bone fracture directions. Accordingly boost aged people quality of life. Decrease with osteoporosis bone fracture induce aged people mortality rate to increase. Investigation syllabus Screening community osteoporosis high-risk group,Program healthy education nourishment,mode of life community intervention.Exploration accommodation feasible low cost, prevention and cure osteoporosis bone fracture. Investigation to aim directly at age critique above two years women random multicentric large scale clinical trial, Of effective intervention models of osteoporosis observed fracture control rate to improve the quality of life of older persons.
Research methods:①Subjects,female age55-75, menostasis above two years.Based on the program selection and exclusion criteria established,600 were selected as subjects at high risk of osteoporosis, ②Divide into groups program:divided into 4 groups corresponding to the average intervention,Agroup Ca+VitD2(calcitriol),Regular health education.Dailysupplement of calcium600mg+VitD2(calcitriol)1,25(OH)2D3) 0.25
μg. Bgroup:Ca+general VitD,Regular health education.Dailysupplement
of Ca+VitD800IU. C group:
Strengthening exercise group Regular health education,unified Sports training. D group:control group,maintain the original way of life.③Effectiveness evaluation:Key indicators:Between groups were compared 1 year of clinical vertebral and non vertebral fracture incidence,
Statistical analysis of whether the intervention group decreased fracture risk and what interventions are most effective;
Between the groups compared the bone pain levels within 1 year and fall times differences in quality of life.
Statistical analysis of the intervention group was able to reduce the times of falls,
reduce bone pain, improve quality of life.④Safety Evaluation:
To the incidence of adverse events and laboratory tests to be evaluated.
The general condition before treatment and was no statistical difference in demographic characteristics.The end of treatment, Effectiveness Evaluation:
Each group before and after the pain score difference of one year, A group -0.71±1.04; B group -0.47±0.75; C group-0.62±0.81; D group 0.19±0.47. The intervention group and control group statistically significant difference compared.b(P＜0.001).
A group 32 case, B group 38 case, C group 31 case, D group 56 case.
The intervention group and control group were statistically significant.(P＜0.005).
The intervention was not statistically significant between groups. （P＞0.005）.③Intervening period the incidence of new fractures A group
1 case(0.68%), B group 2 case(1.44%), C group0 case(0.00%), D group 2 case(1.44%).
After Fisher exact test( P=0.4942),
no significant difference.
No serious adverse events about group were report.
During the one-year osteoporosis intervention in high risk communities，A group Ca+VitD2(calcitriol) The effect of prevention and treatment of osteoporosis and improved quality of life is most evident,
Calcium+ordinary VitD and exercise group efficacy general.
Control group, the worst was not improved. However, the effectiveness for preventing fractures,
need to continue to observe.
high risk of osteoporosis；screening；prevention of fractures ；intervention